Mac and Cheese Meatloaf Casserole

If you’re looking for the perfect comfort food, Mac and Cheese Meatloaf Casserole is a dish you absolutely need to try. This recipe is a brilliant fusion of two all-time favorites: the rich, hearty flavor of meatloaf and the creamy, cheesy goodness of macaroni and cheese. It’s a family-friendly meal that’s great for weeknight dinners, potlucks, or even meal prep.

Imagine a juicy, flavorful meatloaf base topped with homemade mac and cheese, all baked together to perfection. The result? A delicious, cheesy, and meaty dish that will have everyone asking for seconds! Whether you’re a fan of traditional comfort food or looking for a fun twist on classic meals, this recipe has something for you.

In this article, I’ll walk you through everything you need to know—from the ingredients and step-by-step instructions to storage tips and variations. So, let’s get started and make this mouthwatering casserole together!

Why You’ll Love This Recipe

✔️ Two Comfort Foods in One – Combines the best of meatloaf and mac and cheese.
✔️ Perfect for Family Dinners – A filling and satisfying meal that everyone will love.
✔️ Great for Meal Prep – Can be made ahead of time and stored for later.
✔️ Customizable – Easily tweak ingredients to fit your taste.
✔️ Crowd-Pleaser – Ideal for gatherings, potlucks, or cozy nights in.

Ingredients Needed

A top-down view of ingredients for mac and cheese meatloaf casserole.

To make this delicious casserole, you’ll need two main sets of ingredients—one for the meatloaf base and another for the creamy mac and cheese topping.

For the Meatloaf Layer:

  • 1 ½ lbs ground beef (or a mix of beef and pork)
  • ½ cup breadcrumbs (plain or seasoned)
  • 1 egg
  • ½ cup milk
  • ½ cup ketchup
  • 1 tablespoon Worcestershire sauce
  • 1 teaspoon garlic powder
  • 1 teaspoon onion powder
  • ½ teaspoon salt
  • ½ teaspoon black pepper

For the Mac and Cheese Layer:

  • 2 cups elbow macaroni (uncooked)
  • 2 tablespoons butter
  • 2 tablespoons all-purpose flour
  • 1 ½ cups milk (whole or 2%)
  • 2 cups shredded cheddar cheese
  • ½ teaspoon salt
  • ½ teaspoon black pepper
  • ¼ teaspoon paprika (optional, for extra flavor)

Optional Toppings:

  • ½ cup shredded mozzarella or more cheddar cheese (for extra cheesiness)
  • ¼ cup breadcrumbs (for a crispy topping)
  • Chopped fresh parsley (for garnish)

Kitchen Tools Required

Before we start cooking, make sure you have these essential kitchen tools:

Mixing bowls – For combining the meatloaf ingredients.
Baking dish (9×13 inch) – To bake the casserole.
Saucepan – To prepare the cheese sauce.
Whisk – For stirring the cheese sauce.
Wooden spoon or spatula – To mix ingredients properly.
Aluminum foil – To cover the casserole while baking (optional).

Step-by-Step Instructions

Now that we have our ingredients and tools ready, let’s dive into making this delicious Mac and Cheese Meatloaf Casserole step by step.

Step 1: Preheat the Oven

Before you start preparing the ingredients, preheat your oven to 375°F (190°C). This ensures that the casserole bakes evenly and comes out perfectly cooked.

How to Make the Meatloaf Base

The meatloaf base is the foundation of this dish, providing a rich and savory flavor that pairs wonderfully with the mac and cheese topping.

Step 2: Prepare the Meatloaf Mixture

1️⃣ In a large mixing bowl, combine the ground beef, breadcrumbs, egg, milk, ketchup, Worcestershire sauce, garlic powder, onion powder, salt, and black pepper.
2️⃣ Use your hands or a spoon to mix everything thoroughly until all ingredients are well incorporated. Be careful not to overmix, as this can make the meatloaf dense and tough.

Step 3: Shape and Bake the Meatloaf

1️⃣ Lightly grease a 9×13-inch baking dish with non-stick spray or butter.
2️⃣ Press the meatloaf mixture evenly into the bottom of the dish, forming a flat and even layer.
3️⃣ Place the dish in the preheated oven and bake for 20-25 minutes or until the meat is nearly cooked through. The meat should be slightly firm but not fully done, as it will continue cooking with the mac and cheese layer.

🔹 Tip: If you like a little extra tang, spread an additional thin layer of ketchup over the meatloaf before baking.

How to Prepare the Mac and Cheese Layer

While the meatloaf is baking, let’s make the creamy homemade mac and cheese that will go on top.

Step 4: Cook the Pasta

1️⃣ Bring a large pot of salted water to a boil.
2️⃣ Add the elbow macaroni and cook according to the package instructions (usually 7-8 minutes) until al dente.
3️⃣ Drain the pasta and set aside.

🔹 Tip: Toss the drained pasta with a little butter to prevent it from sticking together.

Step 5: Make the Cheese Sauce

1️⃣ In a medium saucepan, melt the butter over medium heat.
2️⃣ Once melted, stir in the flour and whisk constantly for about 1 minute to form a roux.
3️⃣ Gradually pour in the milk, whisking continuously until the mixture is smooth and begins to thicken (about 2-3 minutes).
4️⃣ Reduce the heat to low and stir in the shredded cheddar cheese, salt, pepper, and paprika.
5️⃣ Continue stirring until the cheese is fully melted and the sauce is creamy and smooth.

🔹 Tip: If the sauce is too thick, add a splash of extra milk to reach your desired consistency.

Step 6: Combine Pasta with Cheese Sauce

1️⃣ Pour the cooked macaroni into the cheese sauce and stir well, ensuring all the pasta is evenly coated.
2️⃣ Taste and adjust seasoning if needed.

Assembling the Casserole

Now that both the meatloaf and mac and cheese layers are ready, it’s time to put everything together!

Step 7: Layer the Mac and Cheese Over the Meatloaf

1️⃣ Remove the baking dish with the partially cooked meatloaf from the oven.
2️⃣ Carefully spread the mac and cheese evenly over the meatloaf layer.
3️⃣ If you love extra cheesiness, sprinkle additional shredded cheese on top.

Baking and Cooking Tips

Step 8: Bake Until Golden and Bubbly

1️⃣ Return the assembled casserole to the oven and bake for 15-20 more minutes, or until the cheese is melted and slightly golden on top.
2️⃣ If you like a crispy top, turn on the broiler for the last 2-3 minutes to achieve a beautiful golden crust.

🔹 Tip: Let the casserole rest for about 5 minutes before serving. This helps it set and makes slicing easier.

Variations and Customizations

A freshly baked slice of mac and cheese meatloaf casserole on a plate.

One of the best things about Mac and Cheese Meatloaf Casserole is how customizable it is. You can tweak the recipe to fit your taste preferences or dietary needs. Here are some fun variations to try:

1. Protein Swaps

  • Turkey or Chicken Meatloaf – Substitute ground beef with ground turkey or chicken for a leaner option.
  • Meatless Version – Use plant-based ground meat alternatives to make a vegetarian-friendly version.

2. Cheese Varieties

  • Swap cheddar cheese for Gouda, Monterey Jack, Pepper Jack, or Swiss to add different flavors.
  • Use a blend of cheeses for a more complex, gourmet taste.

3. Add Extra Ingredients to the Mac and Cheese

  • Bacon Crumbles – Adds a smoky, crispy touch.
  • Jalapeños or Hot Sauce – For a spicy kick.
  • Caramelized Onions or Mushrooms – Enhances the richness of the dish.
  • Spinach or Broccoli – A sneaky way to add veggies.

4. Topping Ideas

  • Breadcrumbs & Butter – For a crispy, golden crust.
  • More Cheese! – A sprinkle of Parmesan or mozzarella on top for extra cheesiness.
  • French Fried Onions – Adds a crunchy, flavorful twist.

What to Serve with Mac and Cheese Meatloaf Casserole

This casserole is already a hearty dish on its own, but pairing it with the right sides can make it even better!

Best Side Dishes:

🥗 Green Salad – A fresh, crisp salad balances the richness of the casserole.
🥦 Steamed or Roasted Vegetables – Broccoli, carrots, or asparagus work well.
🥖 Garlic Bread – Because everything is better with garlic bread!
🥒 Pickles or Coleslaw – Adds a tangy contrast to the cheesy meatloaf.

Storage and Reheating Instructions

If you have leftovers, don’t worry—this casserole stores and reheats beautifully!

Refrigeration:

  • Store leftovers in an airtight container and refrigerate for up to 4 days.

Freezing:

  • For longer storage, freeze individual portions or the entire casserole in a freezer-safe container for up to 3 months.
  • To reheat, thaw in the refrigerator overnight before warming up.

Reheating:

  • Oven: Cover with foil and bake at 350°F (175°C) for 15-20 minutes.
  • Microwave: Heat in 30-second intervals until warmed through.

🔹 Tip: Add a splash of milk before reheating to keep the mac and cheese creamy.

Common Mistakes to Avoid

Even though this recipe is simple, a few common mistakes could affect the final dish. Here’s how to avoid them:

❌ Overmixing the Meatloaf – This can make it dense instead of tender. Mix until just combined.
❌ Overcooking the Pasta – Remember, it will continue cooking in the oven. Cook it to al dente.
❌ Not Letting It Rest – Letting the casserole sit for a few minutes before serving helps it set and makes slicing easier.
❌ Forgetting to Grease the Pan – A well-greased pan prevents sticking and makes cleanup easier.

Frequently Asked Questions (FAQs)

1. Can I make this casserole ahead of time?

Yes! You can assemble it up to a day in advance, cover it, and store it in the fridge. When ready to bake, just pop it in the oven and bake as directed. If you’re making a classic mac and cheese for this dish, you might want to check out Tini’s Mac and Cheese Recipe – Creamy, Cheesy, and Perfect for extra inspiration.

2. Can I use store-bought mac and cheese?

Absolutely! If you’re short on time, you can use pre-made mac and cheese or a boxed version. Just make sure it’s not too runny. If you’re wondering how to make it thicker and richer, How to Make a Roux for Mac and Cheese can help you with tips for a perfect cheese sauce.

3. What’s the best type of cheese for this recipe?

Sharp cheddar is a classic choice, but you can mix it with Gouda, Swiss, or mozzarella for extra flavor.

4. How do I make this casserole spicier?

Try adding hot sauce, cayenne pepper, or chopped jalapeños to the meatloaf or cheese sauce. Looking for even more ways to jazz up your mac and cheese flavors? What Goes with Mac and Cheese? Perfect Pairings Guide gives ideas on mix-ins and toppings.

5. Can I use different types of pasta?

Yes! While elbow macaroni is traditional, penne, shell pasta, or rotini also work well.

Conclusion

There you have it—the ultimate Mac and Cheese Meatloaf Casserole! This dish is the perfect blend of cheesy, creamy, and meaty goodness, making it a guaranteed hit for any occasion. Whether you’re making it for a cozy family dinner, meal prep, or even a party, this recipe is sure to impress.

So why wait? Gather your ingredients, follow the simple steps, and treat yourself to this comfort food masterpiece today!